Persistent Hypokalemic Paralysis in a Patient with Graves’ Disease and Gitelman Syndrome

ABSTRACT

Thyrotoxic periodic paralysis (TPP) is a potentially life-threatening condition. Graves’ disease accounts for the majority of cases of TPP. However, another diagnosis should be considered when repeated hypokalemic paralysis occurs in patients that maintain a euthyroid status. In this study, we report a case of persistent hypokalemic paralysis in a patient with Graves’ disease and Gitelman syndrome and provide a brief review of Gitelman syndrome focused on challenges with diagnosis and management when it is accompanied by TPP.