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Severe Acidosis after Massive Metformin Overdose
Journal of The Korean Society of Clinical Toxicology ; : 42-44, 2008.
Artigo em Coreano | WPRIM | ID: wpr-91536
ABSTRACT
Metformin which is an oral hypoglycemic agents, acts by enhancing insulin sensitivity, decreasing hepatic glucose production and increasing peripheral utilization of glucose. Deliberate self poisoning with oral hypoglycemic agents is rare. The lactic acidosis associated with metformin toxicity is well described in the medical literature. Metformin overdose even in otherwise healthy patients may produce a profound and life threatening lactic acidosis. We report a case of massive metformin ingestion(75g) in a patient presenting with lactic acidosis and hypotension. She died 24h after presenting to our emergency department despite bicarbonate treatment and hemofiltration therapy.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Acidose / Acidose Láctica / Resistência à Insulina / Hemofiltração / Emergências / Glucose / Hipoglicemiantes / Hipotensão / Metformina Limite: Humanos Idioma: Coreano Revista: Journal of The Korean Society of Clinical Toxicology Ano de publicação: 2008 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Acidose / Acidose Láctica / Resistência à Insulina / Hemofiltração / Emergências / Glucose / Hipoglicemiantes / Hipotensão / Metformina Limite: Humanos Idioma: Coreano Revista: Journal of The Korean Society of Clinical Toxicology Ano de publicação: 2008 Tipo de documento: Artigo