The effect of 4-hexylresorinol administration on NAD+ level and SIRT activity in Saos-2 cells / 대한악안면성형재건외과학회지
Maxillofacial Plastic and Reconstructive Surgery
;
: 39-2021.
Artigo
em Inglês
| WPRIM
| ID: wpr-918457
ABSTRACT
Background@#4-hexylresorcinol (4HR) has been shown to have anti-oxidant activity similar to that of resveratrol. As resveratrol increases sirtuin (SIRT) activity, 4HR might behave similarly to resveratrol.Method:
In this study, the expression levels of SIRT1, SIRT3, and SIRT6 were evaluated after 4HR administration (1–100 μM). As NAD+ is a substrate for SIRTs, its levels with SIRT activity were also studied. @*Results@#In the results, SIRT3 (100 μM at 24 h) and SIRT6 (1–100 μM at 24 h and 10 μM at 8 h) were shown to have significantly higher expression levels compared to untreated control (p < 0.05). Pan-SIRT activity and the NAD+ level was significantly increased compared to that of the untreated control (p < 0.05; 10 and 100 μM at 24 h). @*Conclusion@#4HR administration increased SIRT activity and the NAD+ level in Saos-2 cells.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Inglês
Revista:
Maxillofacial Plastic and Reconstructive Surgery
Ano de publicação:
2021
Tipo de documento:
Artigo
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