IgG4-Related Intracranial Hypertrophic Pachymeningitis : A Case Report and Review of the Literature
Journal of Korean Neurosurgical Society
;
: 300-302, 2014.
Artigo
em Inglês
| WPRIM
| ID: wpr-92000
ABSTRACT
Hypertrophic pachymeningitis is an uncommon disorder that causes a localized or diffuse thickening of the dura mater. Recently, the possibility that IgG4-related sclerosing disease may underlie some cases of intracranial hypertrophic pachymeningitis has been suggested. We herein report the tenth case of IgG4-related intracranial hypertrophic pachymeningitis and review the previous literature. A 45-year-old male presented with left-sided focal seizures with generalization. Magnetic resonance imaging (MRI) revealed a diffuse thickening and enhancement of the right convexity dura matter and falx with focal nodularity. The surgically resected specimens exhibited the proliferation of fibroblast-like spindle cells and an infiltration of mononuclear cells, including predominantly plasma cells. The ratio of IgG4-positive plasma cells to the overall IgG-positive cells was 45% in the area containing the highest infiltration of plasma cells. On the basis of the above findings, IgG4-related sclerosing disease arising from the dura mater was suspected. IgG4-related sclerosing disease should be added to the pachymeningitis spectrum.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Plasmócitos
/
Convulsões
/
Imuno-Histoquímica
/
Imageamento por Ressonância Magnética
/
Dura-Máter
/
Generalização Psicológica
/
Meningite
Limite:
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Journal of Korean Neurosurgical Society
Ano de publicação:
2014
Tipo de documento:
Artigo
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