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Clinical pathological expert consensus on HER-2 testing in urothelial carcinoma in China / 中华肿瘤杂志
Chinese Journal of Oncology ; (12): 1001-1006, 2021.
Artigo em Chinês | WPRIM | ID: wpr-920981
ABSTRACT
Human epidermal growth factor receptor 2 (HER-2) plays an important role in carcinogenesis and development of urothelial carcinoma. Overexpression of HER-2 is associated with poor prognosis of urothelial carcinoma. Although there is no significant benefit from anti-HER-2 targeted therapies of monoclonal antibody and tyrosine kinase inhibitor, Anti-HER-2 antibody-drug conjugate (HER-2-ADC) has shown a promising efficacy in urothelial carcinoma patients with HER-2 overexpression. Therefore, effectively screening the potential beneficiaries of HER-2-ADC drugs has become a new challenge. However, standardized HER-2 scoring system for urothelial carcinoma has yet to be developed. Thus, the Committees organized experts to reach this expert consensus based on the clinical practice of HER-2 expression, gene amplification and mutation testing in urothelial carcinoma, combined with the current research progress and internal discussion of committee members, in order to construct HER-2 testing standard of urothelial carcinoma and improve the accuracy of interpretation, to guide the clinical application.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Neoplasias da Bexiga Urinária / Carcinoma de Células de Transição / Receptor ErbB-2 / Consenso Tipo de estudo: Guia de Prática Clínica / Estudo prognóstico / Pesquisa qualitativa Limite: Humanos Idioma: Chinês Revista: Chinese Journal of Oncology Ano de publicação: 2021 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Neoplasias da Bexiga Urinária / Carcinoma de Células de Transição / Receptor ErbB-2 / Consenso Tipo de estudo: Guia de Prática Clínica / Estudo prognóstico / Pesquisa qualitativa Limite: Humanos Idioma: Chinês Revista: Chinese Journal of Oncology Ano de publicação: 2021 Tipo de documento: Artigo