Role and mechanism of necrostin-1 in promoting oxidative stress response of macrophages in high glucose condition / 华西口腔医学杂志
West China Journal of Stomatology
;
(6): 675-681, 2021.
Artigo
em Inglês
| WPRIM
| ID: wpr-921390
ABSTRACT
OBJECTIVES@#To investigate the role and molecular mechanism of necrostatin-1 (Nec-1), a specific programmed cell necrosis inhibitor, in promoting the oxidative stress response of macrophages under high glucose (HG) environment.@*METHODS@#Macrophages were cultured in control (5.5 mmol·L@*RESULTS@#The HG group had increased ROS level and MDA activity (@*CONCLUSIONS@#HG promotes oxidative stress on macrophages by upregulating RIP1 expression.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Espécies Reativas de Oxigênio
/
Estresse Oxidativo
/
Glucose
/
Macrófagos
/
Necrose
Limite:
Humanos
Idioma:
Inglês
Revista:
West China Journal of Stomatology
Ano de publicação:
2021
Tipo de documento:
Artigo
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