Natural medicinal ingredients induce tumor ferroptosis and related mechanisms / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 601-606, 2021.
Artigo
em Inglês
| WPRIM
| ID: wpr-922257
ABSTRACT
Ferroptosis is an iron-dependent programmed cell death characterized by reactive oxygen species-induced lipid peroxide accumulation, which is different from cell apoptosis, pyroptosis, necrosis or autophagy. Ferroptosis plays an important role in the regulation of tumorigenesis and tumor development. Recent studies have shown that natural medicinal ingredients can induce ferroptosis in tumor cells through glutathione (GSH)/glutathione peroxidase 4 (GPx4) pathway, iron metabolism, lipid metabolism or other mechanisms. It has been reported that more than 30 natural medicinal ingredients can induce ferroptosis in tumor cells with multiple pathways and multiple targets. This article reviews the current research progress on the antitumor effects of natural medicinal ingredients through inducing cell ferroptosis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Autofagia
/
Espécies Reativas de Oxigênio
/
Apoptose
/
Ferroptose
/
Neoplasias
Limite:
Humanos
Idioma:
Inglês
Revista:
Journal of Zhejiang University. Medical sciences
Ano de publicação:
2021
Tipo de documento:
Artigo
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