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Clinical Significance of EBV-DNA Copy Number in EBV Positive Lymphoma Patients / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 1785-1789, 2021.
Artigo em Chinês | WPRIM | ID: wpr-922335
ABSTRACT
OBJECTIVE@#To investigate the effect of EBV-DNA copy number on the prognosis of patients with EBV positive lymphoma.@*METHODS@#Clinical data of 109 patients diagnosed as EBV positive lymphoma in Tianjin Medical University Cancer Institute and Hospital from January 2010 to January 2020 were enrolled and analyzed retrospectively. Kaplan-Meier analysis was used for survival analysis, Log-rank was used to compare the clinical characteristics between the patients in different groups, and Cox regression was used for multivariate analysis.@*RESULTS@#Among the 109 patients with EBV-positive lymphoma, the medium age were 56 (range 15 to 83) years old. 29 patients at Ann Arbor stage I-II while 80 patients at stage III-IV. The average value of EBV-DNA was 1 023 510 IU/ml, 7 patients were higher than the average value, while 102 patients were lower. KM survival analysis showed that OS and PFS in patients with EBV-DNA above average level were shorter than those in patients with EBV-DNA below average level (OS P=0.048, PFS P=0.001), EBV-DNA copy number was a factor affecting the prognosis of patients. In addition, LDH level showed positive correlation with EBV-DNA copy number (r=0.650), which was also one of the factors affecting OS (P=0.053).@*CONCLUSION@#EBV-DNA copy number and LDH level can influence the prognosis of EBV positive lymphoma patients. Therefore, detection of EBV-DNA copy number in peripheral blood is important for evaluate the prognosis the patients.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: DNA Viral / Estudos Retrospectivos / Herpesvirus Humano 4 / Variações do Número de Cópias de DNA / Linfoma Tipo de estudo: Estudo observacional / Estudo prognóstico Limite: Adolescente / Adulto / Idoso / Aged80 / Humanos Idioma: Chinês Revista: Journal of Experimental Hematology Ano de publicação: 2021 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: DNA Viral / Estudos Retrospectivos / Herpesvirus Humano 4 / Variações do Número de Cópias de DNA / Linfoma Tipo de estudo: Estudo observacional / Estudo prognóstico Limite: Adolescente / Adulto / Idoso / Aged80 / Humanos Idioma: Chinês Revista: Journal of Experimental Hematology Ano de publicação: 2021 Tipo de documento: Artigo