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Analysis of Initial Baseline Clinical Parameters and Treatment Strategy Associated with Medication Failure in the Treatment of Benign Prostatic Hyperplasia in Korea / 대한배뇨장애요실금학회지
International Neurourology Journal ; : 261-266, 2010.
Artigo em Inglês | WPRIM | ID: wpr-92244
ABSTRACT

PURPOSE:

To analyze the baseline clinical factors and medication treatment strategy used in cases with medication treatment failure of benign prostatic hyperplasia (BPH).

METHODS:

From January 2006 to December 2009, 677 BPH patients with at least 3 months of treatment with medication were enrolled. We analyzed clinical factors by medication failure (n=161) versus maintenance (n=516), by prostate size (less than 30 g, n=231; 30 to 50 g, n=244; greater than 50 g, n=202), and by prostate-specific antigen (PSA) levels (less than 1.4 ng/mL, n=324; more than 1.4 ng/mL, n=353).

RESULTS:

Age, combination medication rate, PSA, and prostate volume were statistically different between the medication treatment failure and maintenance groups. By prostate size, the PSA and medication failure rates were relatively higher and the medication period was shorter in patients with a prostate size of more than 30 g. The combination medication rate was higher in patients with a prostate size of more than 50 g. The medication failure rate and prostate volume were higher in patients with a PSA level of more than 1.4 ng/mL. However, the combination treatment rate was not significantly different in patients with a PSA level lower than 1.4 ng/mL. Suggestive cutoffs for combination medication are a prostate volume of 34 g and PSA level of 1.9 ng/mL.

CONCLUSIONS:

The clinical factors associated with medication failure were age, treatment type, and prostate volume. Combination therapy should be considered more in Korea in patients with a PSA level higher than 1.4 ng/mL and a prostate volume of between 30 and 50 g to prevent medication failure.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Próstata / Hiperplasia Prostática / Falha de Tratamento / Antígeno Prostático Específico / Coreia (Geográfico) Limite: Humanos País/Região como assunto: Ásia Idioma: Inglês Revista: International Neurourology Journal Ano de publicação: 2010 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Próstata / Hiperplasia Prostática / Falha de Tratamento / Antígeno Prostático Específico / Coreia (Geográfico) Limite: Humanos País/Região como assunto: Ásia Idioma: Inglês Revista: International Neurourology Journal Ano de publicação: 2010 Tipo de documento: Artigo