Proteomics and metabolic phenotyping define principal roles for the aryl hydrocarbon receptor in mouse liver

Jian JIN; Banrida WAHLANG; Monika THAPA; Kimberly-Z HEAD; Josiah-E HARDESTY; Sudhir SRIVASTAVA; Michael-L MERCHANT; Shesh-N RAI; Russell-A PROUGH; Matthew-C CAVE

Jian JIN; Banrida WAHLANG; Monika THAPA; Kimberly-Z HEAD; Josiah-E HARDESTY; Sudhir SRIVASTAVA; Michael-L MERCHANT; Shesh-N RAI; Russell-A PROUGH; Matthew-C CAVE.

Acta Pharmaceutica Sinica B ; (6): 3806-3819, 2021.

Artigo em Inglês | WPRIM | ID: wpr-922442

ABSTRACT

ABSTRACT

Dioxin-like molecules have been associated with endocrine disruption and liver disease. To better understand aryl hydrocarbon receptor (AHR) biology, metabolic phenotyping and liver proteomics were performed in mice following ligand-activation or whole-body genetic ablation of this receptor. Male wild type (WT) and

AHR; AHR, aryl hydrocarbon receptor; ALT, alanine transaminase; ANOVA, analysis of variance; AST, aspartate transaminase

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Tipo de estudo: Estudo prognóstico Idioma: Inglês Revista: Acta Pharmaceutica Sinica B Ano de publicação: 2021 Tipo de documento: Artigo

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