Ferroptosis, radiotherapy, and combination therapeutic strategies
Protein & Cell
; (12): 836-857, 2021.
Article
em En
| WPRIM
| ID: wpr-922483
Biblioteca responsável:
WPRO
ABSTRACT
Ferroptosis, an iron-dependent form of regulated cell death driven by peroxidative damages of polyunsaturated-fatty-acid-containing phospholipids in cellular membranes, has recently been revealed to play an important role in radiotherapy-induced cell death and tumor suppression, and to mediate the synergy between radiotherapy and immunotherapy. In this review, we summarize known as well as putative mechanisms underlying the crosstalk between radiotherapy and ferroptosis, discuss the interactions between ferroptosis and other forms of regulated cell death induced by radiotherapy, and explore combination therapeutic strategies targeting ferroptosis in radiotherapy and immunotherapy. This review will provide important frameworks for future investigations of ferroptosis in cancer therapy.
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Texto completo:
1
Índice:
WPRIM
Assunto principal:
Radioterapia
/
Ferroptose
/
Imunoterapia
/
Neoplasias
Limite:
Humans
Idioma:
En
Revista:
Protein & Cell
Ano de publicação:
2021
Tipo de documento:
Article