ERα promotes transcription of tumor suppressor gene / 浙江大学学报(英文版)(B辑:生物医学和生物技术)
Journal of Zhejiang University. Science. B
;
(12): 1034-1044, 2021.
Artigo
em Inglês
| WPRIM
| ID: wpr-922561
ABSTRACT
Apolipoprotein A-I (ApoA-I), the main protein component of high-density lipoprotein (HDL), plays a pivotal role in reverse cholesterol transport (RCT). Previous studies indicated a reduction of serum ApoA-I levels in various types of cancer, suggesting ApoA-I as a potential cancer biomarker. Herein, ectopically overexpressed ApoA-I in MDA-MB-231 breast cancer cells was observed to have antitumor effects, inhibiting cell proliferation and migration. Subsequent studies on the mechanism of expression regulation revealed that estradiol (E2)/estrogen receptor α (ERα) signaling activates
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Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Inglês
Revista:
Journal of Zhejiang University. Science. B
Ano de publicação:
2021
Tipo de documento:
Artigo
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