Danshen-Chuanxiongqin Injection attenuates cerebral ischemic stroke by inhibiting neuroinflammation via the TLR2/ TLR4-MyD88-NF-κB Pathway in tMCAO mice / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 772-783, 2021.
Artigo
em Inglês
| WPRIM
| ID: wpr-922760
ABSTRACT
Danshen-Chuanxiongqin Injection (DCI) is a commonly used traditional Chinese medicine for the treatment of cerebral ischemic stroke in China. However, its underlying mechanisms remain completely understood. The current study was designed to explore the protective mechanisms of DCI against cerebral ischemic stroke through integrating whole-transcriptome sequencing coupled with network pharmacology analysis. First, using a mouse model of cerebral ischemic stroke by transient middle cerebral artery occlusion (tMCAO), we found that DCI (4.10 mL·kg
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Medicamentos de Ervas Chinesas
/
Isquemia Encefálica
/
NF-kappa B
/
Acidente Vascular Cerebral
/
Infarto da Artéria Cerebral Média
/
Receptor 2 Toll-Like
/
Receptor 4 Toll-Like
/
Fator 88 de Diferenciação Mieloide
/
AVC Isquêmico
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Ano de publicação:
2021
Tipo de documento:
Artigo
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