Region Specific Brain Organoids to Study Neurodevelopmental Disorders
International Journal of Stem Cells
; : 26-40, 2022.
Article
em En
| WPRIM
| ID: wpr-925075
Biblioteca responsável:
WPRO
ABSTRACT
Region specific brain organoids are brain organoids derived by patterning protocols using extrinsic signals as opposed to cerebral organoids obtained by self-patterning. The main focus of this review is to discuss various region-specific brain organoids developed so far and their application in modeling neurodevelopmental disease. We first discuss the principles of neural axis formation by series of growth factors, such as SHH, WNT, BMP signalings, that are critical to generate various region-specific brain organoids. Then we discuss various neurodevelopmental disorders modeled so far with these region-specific brain organoids, and findings made on mechanism and treatment options for neurodevelopmental disorders (NDD).
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1
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WPRIM
Tipo de estudo:
Guideline
/
Prognostic_studies
Idioma:
En
Revista:
International Journal of Stem Cells
Ano de publicação:
2022
Tipo de documento:
Article