Research progress of pharmacokinetic factors of metformin / 中国药房
China Pharmacy
;
(12): 1513-1519, 2022.
Artigo
em Chinês
| WPRIM
| ID: wpr-927201
ABSTRACT
Metformin is the most common first-line oral hypoglycemic drug ,but there are large individual differences in pharmacokinetic parameters and pharmacodynamics during clinical use. The dosage of some patients should be adjusted to achieve satisfactory therapeutic effect. Pharmacokinetic parameters of metformin are affected by many factors ,including respects of transporter gene polymorphism ,drug interaction ,intestinal flora ,plateau hypoxia and physiological function and so on. In order to guide the clinical individualized use of metformin ,this study reviews the research progress on the influencing factors of metformin pharmacokinetics.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
China Pharmacy
Ano de publicação:
2022
Tipo de documento:
Artigo
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