Research progress of vascular endothelial growth factor-A and its isoforms in kidney disease / 生理学报
Acta Physiologica Sinica
;
(6): 59-66, 2022.
Artigo
em Chinês
| WPRIM
| ID: wpr-927581
ABSTRACT
Vascular endothelial growth factor-A (VEGF-A) is a critical angiogenic factor which is mainly secreted from podocytes and epithelial cells in kidney and plays an important role in renal pathophysiology. In recent years, functions of different isoforms of VEGF-A and the new secretion approach via extracellular vesicles (EVs) have been identified. Thus, further understanding are needed for the role of VEGF-A and its isoforms in renal injury and repair. In this review, we summarized the expression, secretion and regulation of VEGF-A, its biological function, and the role of different isoforms of VEGF-A in the development of different renal diseases. Meanwhile, the research progress of VEGF-A as diagnostic marker and therapeutic target for renal diseases were discussed.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Isoformas de Proteínas
/
Fator A de Crescimento do Endotélio Vascular
/
Rim
/
Nefropatias
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Chinês
Revista:
Acta Physiologica Sinica
Ano de publicação:
2022
Tipo de documento:
Artigo
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