Advances on human amniotic epithelial cells and its clinical application potential / 生理学报
Acta Physiologica Sinica
;
(6): 80-92, 2022.
Artigo
em Chinês
| WPRIM
| ID: wpr-927584
ABSTRACT
Human amniotic epithelial cells (hAECs) are epithelial cells located on the placental amnion near the fetus. Different from other placental-derived stem cells, hAECs are derived from embryonic epiblast, and have been considered as seed cells for regenerative medicine. hAECs possess embryonic stem cell-like multi-differentiation capabilities and adult stem cell-like immunomodulatory properties. Compared with other types of stem cells, special properties of hAECs make them unique, including easy isolation, abundant cell numbers, non-tumorigenicity after transplantation, and the obviation of ethical debates. During the past two decades, the therapeutic potential of hAECs has been extensively investigated in various diseases. Accumulating evidence has demonstrated that hAECs contribute to repairing and remodeling the function of damaged tissues and organs through different molecular mechanisms. This article provides an in-depth review of the biological characteristics of hAECs, summarizes the research status of hAECs, and discusses the clinical application prospects of hAEC-based cell therapy.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Placenta
/
Células-Tronco
/
Diferenciação Celular
/
Células Epiteliais
/
Âmnio
Limite:
Feminino
/
Humanos
/
Gravidez
Idioma:
Chinês
Revista:
Acta Physiologica Sinica
Ano de publicação:
2022
Tipo de documento:
Artigo
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