Short-Term Autonomic Denervation of the Atria Using Botulinum Toxin
Korean Circulation Journal
;
: 387-390, 2010.
Artigo
em Inglês
| WPRIM
| ID: wpr-9276
ABSTRACT
BACKGROUND AND OBJECTIVES:
Major epicardial fat pads contain cardiac ganglionated plexi (GP) of the autonomic nervous system. Autonomic denervation may improve the success rate of atrial fibrillation (AF) ablation. This study was designed to elucidate the acute effects of blocking the right atrium-pulmonary vein (RA-PV) and left atrium-inferior vena cava (LA-IVC) fat pads on the electrophysiologic characteristics of the atrium and AF inducibility with a botulinum toxin injection. Materials andMethods:
Eight mongrel dogs were studied. The RA-PV and LA-IVC fat pads were exposed through a median thoracotomy. Botulinum toxin (BT, 50 U to each fat pad, n=6) or normal saline (NS, n=2) was injected in the entire area of two fat pads. The study protocol was applied before injection and repeated at 1, 2, 3, 4, and 5 hours thereafter. The sinus rate, ventricular rate during rapid atrial pacing with a cycle length of 50 ms, and AF inducibility were measured with and without vagal stimulation (VS). Bilateral cervical VS was applied (20 Hz, 0.2 ms, 5.6+/-2.0 V). AF inducibility was evaluated with burst pacing with 200 impulses at a 50-ms cycle length.RESULTS:
VS effects on the sinus node and AF inducibility were eliminated a few hours after injection of BT; these changes were not observed after injection of NS.CONCLUSION:
Short-term autonomic denervation of the atria was achieved by blocking the major epicardial GP with BT.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fibrilação Atrial
/
Nó Sinoatrial
/
Sistema Nervoso Autônomo
/
Veias
/
Toxinas Botulínicas
/
Toracotomia
/
Tecido Adiposo
/
Vias Autônomas
/
Denervação Autônoma
/
Cistos Glanglionares
Limite:
Animais
Idioma:
Inglês
Revista:
Korean Circulation Journal
Ano de publicação:
2010
Tipo de documento:
Artigo
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