Progress in the Role of Mechanical Stimulus in Cardiac Development / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 164-172, 2022.
Artigo
em Chinês
| WPRIM
| ID: wpr-927861
ABSTRACT
Mechanical stimulus is critical to cardiovascular development during embryogenesis period.The mechanoreceptors of endocardial cells and cardiac myocytes may sense mechanical signals and initiate signal transduction that induce gene expression at a cellular level,and then translate molecular-level events into tissue-level deformations,thus guiding embryo development.This review summarizes the regulatory roles of mechanical signals in the early cardiac development including the formation of heart tube,looping,valve and septal morphogenesis,ventricular development and maturation.Further,we discuss the potential mechanical transduction mechanisms of platelet endothelial cell adhesion molecule 1-vascular endothelial-cadherin-vascular endothelial growth factor receptor 2 complex,primary cilia,ion channels,and other mechanical sensors that affect some cardiac malformations.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Miócitos Cardíacos
/
Mecanotransdução Celular
/
Fator A de Crescimento do Endotélio Vascular
/
Coração
Limite:
Animais
/
Humanos
Idioma:
Chinês
Revista:
Acta Academiae Medicinae Sinicae
Ano de publicação:
2022
Tipo de documento:
Artigo
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