Immunotherapy Based on Tumor Microenvironment in Renal Cell Carcinoma / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 305-312, 2022.
Artigo
em Chinês
| WPRIM
| ID: wpr-927880
ABSTRACT
Renal cell carcinoma (RCC) is a common lethal urological cancer,the distant metastasis of which is the leading cause of death.Although targeted agents have remarkably improved the overall prognosis of RCC patients,nearly all the patients eventually acquire therapeutic resistance.With the advent of immune checkpoint inhibitors,immunotherapy based on tumor microenvironment (TME) has shown a broad scope in clinical application.The deepening understanding of TME leads to the changes of therapeutic strategies for advanced RCC,and the combination of targeted therapy and immunotherapy is exhibiting a promising prospect.Herein,we reviewed the TME characteristics,candidate predictive biomarkers,and possible targets for future development of drugs against RCC.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Carcinoma de Células Renais
/
Microambiente Tumoral
/
Inibidores de Checkpoint Imunológico
/
Imunoterapia
/
Neoplasias Renais
Tipo de estudo:
Estudo prognóstico
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Acta Academiae Medicinae Sinicae
Ano de publicação:
2022
Tipo de documento:
Artigo
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