A new phloroglucinol from Dryopteris fragrans and its antibacterial activity in vitro / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2474-2479, 2022.
Artigo
em Chinês
| WPRIM
| ID: wpr-928127
ABSTRACT
A new phloroglucinol was isolated from 50% ethanol extract of Dryopteris fragrans by silica gel column chromatography, Sephadex LH-20 gel column chromatography, thin-layer chromatography(TLC), and preparative liquid column chromatography. On the basis of MS, ~1H-NMR, ~(13)C-NMR, and reference materials, compound 1 was identified as 2,5-cyclohexadien-1-one, 2-{[2,6-dihydroxy-4-methoxy-3-methyl-5-(1-isobutyl)phenyl]methyl}-3,5-dihydroxy-4,4-dimethyl-6-(1-oxobutyl)(1), and named disaspidin BB. Compound 1 was evaluated for its antibacterial activity. The experimental results showed that compared with the commonly used topical antibiotics erythromycin or mupirocin, disaspidin BB exhibited significant antibacterial activities against Staphylococcus epidermidis(SEP), S. haemolyticus(SHA), and methicillin-resistant S. aureus(MRSA)(P<0.05). Additionally, disaspidin BB was sensitive to ceftazidime-resistant SEP1-SEP4, SHA5-SHA7, MRSA8, and MRSA9. The MIC values of disaspidin BB against SEP and SHA were 1.67-2.71 μg·mL~(-1) and 10.00-33.33 μg·mL~(-1) respectively. Disaspidin BB has good antibacterial activities and deserves development as a new anti-infective drug for external use.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Floroglucinol
/
Extratos Vegetais
/
Testes de Sensibilidade Microbiana
/
Dryopteris
/
Staphylococcus aureus Resistente à Meticilina
/
Antibacterianos
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2022
Tipo de documento:
Artigo
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