Advances in relationship between cell senescence and atherosclerosis / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 95-101, 2022.
Artigo
em Inglês
| WPRIM
| ID: wpr-928660
ABSTRACT
Cellular senescence is a biological process associated with the degeneration of cell structure and function, which contribute to age-related diseases. Atherosclerosis is a chronic inflammatory disease that can cause a variety of cardiovascular disorders. In this article, we review the effects of cellular senescence on the development of atherosclerosis through diverse physiopathological changes, focusing on the alterations in senescent organelles and the increased senescence-associated secretory phenotype (SASP), and exploring the relevant therapeutic strategies for atherosclerosis by clearing senescent cells and reducing SASP, to provide new insights for the treatment of atherosclerosis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Envelhecimento
/
Doenças Cardiovasculares
/
Doença Crônica
/
Senescência Celular
/
Aterosclerose
/
Fenótipo Secretor Associado à Senescência
Limite:
Humanos
Idioma:
Inglês
Revista:
Journal of Zhejiang University. Medical sciences
Ano de publicação:
2022
Tipo de documento:
Artigo
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