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Research Progress of HO1 on AntiOxidative Stress Injury of MSC --Review / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 613-617, 2022.
Artigo em Chinês | WPRIM | ID: wpr-928762
ABSTRACT
Mesenchymal stem cell (MSC) is widely used in cell therapy because of its high proliferative and multi directional differentiation potential as well as its low immunogenicity. The transplantation of MSC can help the repair of the injured organs, however, the MSC transplanted to the local organs are affected by oxidative stress and lead to premature aging or apoptosis. Heme oxygenase 1 (HO1) is a key ratelimiting enzyme in the process of heme metabolism, which has the functions of antiinflammation, antioxidation, antiapoptosis, antiaging, reducing cell damage and promoting angiogenesis. Induced high expression of HO1 in MSC could increase the ability of MSC against oxidative stress injury, delay the senescence and apoptosis of MSC, and alleviate cell injury. In this reviews, the research progress of HO1 on antioxidative stress injury of MSC.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Diferenciação Celular / Apoptose / Estresse Oxidativo / Transplante de Células-Tronco Mesenquimais / Heme Oxigenase-1 / Células-Tronco Mesenquimais Limite: Humanos Idioma: Chinês Revista: Journal of Experimental Hematology Ano de publicação: 2022 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Diferenciação Celular / Apoptose / Estresse Oxidativo / Transplante de Células-Tronco Mesenquimais / Heme Oxigenase-1 / Células-Tronco Mesenquimais Limite: Humanos Idioma: Chinês Revista: Journal of Experimental Hematology Ano de publicação: 2022 Tipo de documento: Artigo