Dysideanones F-G and dysiherbols D-E, unusual sesquiterpene quinones with rearranged skeletons from the marine sponge Dysidea avara / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 148-154, 2022.
Article
em En
| WPRIM
| ID: wpr-929245
Biblioteca responsável:
WPRO
ABSTRACT
Four new sesquiterpene quinone meroterpenoids, dysideanones F-G (1-2) and dysiherbols D-E (3-4), were isolated from the marine sponge Dysidea avara collected from the South China Sea. The new structures were elucidated by extensive analysis of spectroscopic data including HR-MS and 1D and 2D NMR spectra, and their absolute configurations were assigned by single-crystal X-ray diffraction and ECD calculations. Anti-inflammatory evaluation showed that dysiherbols D-E (3-4) exhibited moderate inhibitory activity on TNF-α-induced NF-κB activation in human HEK-293T cells with IC50 values of 10.2 and 8.6 μmol·L-1, respectively.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Poríferos
/
Quinonas
/
Sesquiterpenos
/
Esqueleto
/
Dysidea
Limite:
Animals
Idioma:
En
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Ano de publicação:
2022
Tipo de documento:
Article