New anti-pulmonary fibrosis prenylflavonoid glycosides from Epimedium koreanum / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 221-228, 2022.
Artigo
em Inglês
| WPRIM
| ID: wpr-929255
ABSTRACT
Four new prenylflavonoid glycosides, namely koreanoside H-K (1-4), together with eleven known ones (5-15) were isolated from the leaves of Epimedium koreanum Nakai. Their structures were elucidated by 1D NMR, 2D NMR, HR-ESI-MS, IR and UV. The identification of the sugar moieties was carried out by means of acid hydrolysis and HPLC analysis of their derivatives. It is worth noting that compound 3 and compound 4 were elucidated to contain fucose and quinovose moieties, which were two extremely rare sugar units from the genus Epimedium. The anti-pulmonary fibrosis activity of the new compounds was evaluated using A549 cell line. Compounds 1, 2 and 4 showed significant anti-pulmonary fibrosis activities.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Extratos Vegetais
/
Cromatografia Líquida de Alta Pressão
/
Folhas de Planta
/
Epimedium
/
Glicosídeos
Idioma:
Inglês
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Ano de publicação:
2022
Tipo de documento:
Artigo
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