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Application of CD47 in targeted therapy strategies for hematologic neoplasms / 白血病·淋巴瘤
Journal of Leukemia & Lymphoma ; (12): 61-64, 2022.
Artigo em Chinês | WPRIM | ID: wpr-929733
ABSTRACT
CD47 is widely expressed on the cell surface, and combines with signal regulatory protein α (SIRPα) to transmit the "don't eat me" signal, which plays a key role in self-recognition and tumor immune escape. Studies have shown that the high expression of CD47 in different hematologic neoplasms is associated with the occurrence, progression and poor prognosis of tumors. As a new immune checkpoint, CD47 is gradually becoming an effective target for tumor immunotherapy. and various related preclinical and clinical studies for hematologic neoplasms are underway. This article summarizes the application of CD47 in hematologic neoplasms, in order to provide references for the treatment.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Journal of Leukemia & Lymphoma Ano de publicação: 2022 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Journal of Leukemia & Lymphoma Ano de publicação: 2022 Tipo de documento: Artigo