Clinical Comparative Study: Efficacy and Tolerability of Tolperisone and Thiocolchicoside in Acute Low Back Pain and Spinal Muscle Spasticity
Asian Spine Journal
;
: 115-122, 2012.
Artigo
em Inglês
| WPRIM
| ID: wpr-92980
ABSTRACT
STUDY DESIGN:
We performed a multicentric, randomized, comparative clinical trial. Eligible patients were randomly assigned to receive 150 mg of Tolperisone thrice daily or 8 mg of Thiocolchicoside twice daily for 7 days.PURPOSE:
To assess the efficacy and tolerability of Tolperisone in comparison with Thiocolchicoside in the treatment of acute low back pain with spasm of spinal muscles. OVERVIEW OF LITERATURE No head on clinical trial of Tolperisone with Thiocolchicoside is available and so this study is done.METHODS:
The assessment of muscle spasm was made by measuring the finger-to-floor distance (FFD), articular excursion in degrees on performing Lasegue's maneuver and modified Schober's test. Assessment of pain on movement and spontaneous pain (pain at rest) of the lumbar spine was made with the help of visual analogue scale score.RESULTS:
The improvement in articular excursion on Lasegue's maneuver was significantly greater on day 3 (p = 0.017) and day 7 (p = 0.0001) with Tolperisone as compared to Thiocolchicoside. The reduction in FFD score was greater on day 7 (p = 0.0001) with Tolperisone. However there was no significant difference in improvement in Schober's test score on day 3 (p = 0.664) and day 7 (p = 0.192). The improvement in pain score at rest and on movement was significantly greater with Tolperisone (p = 0.0001).CONCLUSIONS:
Tolperisone is an effective and well tolerated option for treatment of patients with skeletal muscle spasm associated with pain.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Espasmo
/
Coluna Vertebral
/
Tolperisona
/
Colchicina
/
Dor Lombar
/
Músculo Esquelético
/
Cabeça
/
Espasticidade Muscular
/
Músculos
Tipo de estudo:
Ensaio Clínico Controlado
Limite:
Humanos
Idioma:
Inglês
Revista:
Asian Spine Journal
Ano de publicação:
2012
Tipo de documento:
Artigo
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