Introduction and interpretation of World Health Organization recomended characteristics of monoclonal antibodies for passive immunization against respiratory syncytial virus disease / 中华实用儿科临床杂志

ABSTRACT

Respiratory syncytial virus (RSV) is the main pathogen of respiratory diseases in infants and young children worldwide, and the incidence of severe RSV infection remains highest in infants.Effective preventive measures are urgently needed to prevent RSV infection.Currently, no vaccine has been approved to prevent RSV infection.In June 2021, World Health Organization (WHO) proposed the Characteristics of Monoclonal Antibodies for Passive Immunization against Respiratory Syncytial Virus Infection which facilitates the development of high-quality, safe, affordable and effective monoclonal antibodies to prevent severe RSV infection and deaths in infants and young children worldwide.This study aims to interpret this document, thus guiding pediatricians understand the ideal characteristics and application of monoclonal antibodies for passive immunity to RSV infection.