Research progress of interleukin-17 in offspring autism spectrum disorder / 中华实用儿科临床杂志
Chinese Journal of Applied Clinical Pediatrics
; (24): 718-720, 2022.
Article
em Zh
| WPRIM
| ID: wpr-930504
Biblioteca responsável:
WPRO
ABSTRACT
Interleukin-17 (IL-17) plays an important role in the body′s immune response and inflammatory response.High levels of IL-17 are associated with a variety of autoimmune diseases, acute and chronic neurodegenerative diseases, and psychiatric disorders.Autism spectrum disorder (ASD) is a group of common neurodevelopmental disorders in childhood.Recent clinical and experimental studies have linked maternal immune activation (MIA) during pregnancy to the risk of ASD in offspring.Significantly increased IL-17 level is found in MIA-induced progeny ASD, which is the key factor leading to neurodevelopmental abnormalities in progeny mice.This article reviews the latest research progress on the relationship between IL-17 and progeny ASD, and provides new ideas for the prevention and treatment of ASD.
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1
Índice:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Applied Clinical Pediatrics
Ano de publicação:
2022
Tipo de documento:
Article