Correlation between serum 25(OH)D levels and target organ damage in older adult patients with essential hypertension / 中国基层医药

ABSTRACT

Objective:To measure serum 25-hydroxyvitamin D (25(OH)D) levels in older adult patients with essential hypertension and correlate serum 25(OH)D levels with target organ damage.Methods:The general data and laboratory test results of 163 older adult patients with essential hypertension who received treatment in Zhejiang Veteran Hospital between January 2019 and April 2021 were collected for this study. The included patients were divided into different groups according to the number of injured target organs, serum 25(OH)D level, and single target organ damage site. Two variables were correlated using the Pearson correlation analysis. The factors that affect target organ damage were analyzed using multivariate logistic regression analysis.Results:There were significant differences in age, course of the disease, serum 25(OH)D level, systolic blood pressure, and diastolic blood pressure among patients with different numbers of damaged target organs ( F = 16.95, 14.39, 14.95, 33.18, 20.88, all P < 0.001). There were significant differences in serum triacylglycerol level and 25(OH)D level among the patients who had different serum 25(OH)D levels ( F = 2.31, 178.48, both P < 0.05). There was a negative correlation between serum 25(OH)D levels and serum triacylglycerol levels. Serum 25(OH)D level was significantly lower in patients with damage to a single target organ heart, kidney, or carotid artery than in patients without target organ damage ( t = 9.24, 6.15, 6.09, all P < 0.05). There was no significant difference in serum 25(OH)D level between patients with damage to a single target organ ( P > 0.05). Older age, long course of disease, high systolic and diastolic blood pressure, and low serum 25(OH)D level were the independent risk factors for target organ damage (all P < 0.05). Conclusion:There is a correlation between serum 25(OH)D levels and target organ damage in older adult patients with essential hypertension. However, the evidence of vitamin D deficiency and target organ damage in essential hypertension is still insufficient, and further investigation is needed. This study is highly innovative and scientific.