Subarachnoid anesthesia with ropivacaine combined with sufentanil in cesarean delivery / 中国基层医药

ABSTRACT

Objective:To investigate the efficacy of subarachnoid anesthesia with low-dose ropivacaine combined with sufentanil in cesarean delivery.Methods:A total of 120 women who were subjected to cesarean delivery in Tongxiang Second People's Hospital from May 2017 to April 2018 were included in this study. They were randomly assigned to undergo subarachnoid anesthesia either with low-dose ropivacaine plus sufentanil (observation group, n = 60) or low-dose ropivacaine alone (control group, n = 60) in cesarean delivery. The anesthesia effects, heart rate, mean arterial pressure, sensory block, 1-minute Apgar score, and the incidence of adverse reactions were compared between the two groups. Results:Time to anesthesia onset and time to pain recovery in the observation group were (2.07 ± 1.24) minutes and (51.29 ± 6.24) minutes, respectively, which were significantly shorter than those in the control group [(4.58 ± 1.69) minutes, (56.70 ± 7.91) minutes, t = 9.28, 4.16, both P < 0.05]. There was no significant difference in the duration of anesthesia between the two groups ( t = 0.76, P > 0.05). The heart rate, mean arterial pressure, and 1-minute Apgar score were (77.64 ± 6.20) beats/minute, (92.23 ± 1.38) mmHg, and (9.68 ± 0.70) points respectively in the observation group, which were significantly lower than those in the control group [(83.40 ± 5.93) beats/minute, (96.54 ± 4.06) mmHg, (7.59 ± 0.64) points, t = 5.20, 7.79, 17.07, all P < 0.05]. Time to onset of sensory block was significantly shorter in the observation group than in the control group [(52.07 ± 8.68) seconds vs. (64.30 ± 9.62) seconds, t = 7.31, P < 0.05]. Duration of sensory and motor block in the observation group were (161.75 ± 28.63) minutes and (86.26 ± 20.03) minutes, respectively, which were significantly longer than those in the control group [(130.29 ± 31.84) minutes, (78.60 ± 16.95) minutes, t = 5.69, 2.26, both P < 0.05]. The incidence of adverse reactions was significantly lower in the observation group than in the control group (5.00% vs. 16.67%, χ2 = 4.23, P < 0.05). Conclusion:Subarachnoid anesthesia with low-dose ropivacaine combined with sufentanil has satisfactory anesthetic effects in cesarean delivery. The combined therapy can stabilize hemodynamics, has little impact on newborns, and is highly safe.