Comparative study of serum levels of albumin and hs-CRP in hemodialysis patients according to protein intake levels / 한국영양학회지
Journal of Nutrition and Health
; : 521-530, 2013.
Article
em Ko
| WPRIM
| ID: wpr-93176
Biblioteca responsável:
WPRO
ABSTRACT
Protein-energy malnutrition, PEM, and increased hs-CRP level are considered to be associated with increased risk of cardiovascular disease (CVD) in hemodialysis (HD) patients. This is commonly referred to as the vicious circle of malnutrition-inflammation-atherosclerosis cardiovascular disease (MIA syndrome) in chronic kidney disease (CKD). Low protein intake can decrease the serum level of albumin and increase inflammational markers; further, both low serum albumin and high hs-CRP are independent risk factors for all-cause mortality in HD patients. The aim of this study is comparing the serum levels of albumin and hs-CRP in HD patients according to the protein intake levels. The total number of subjects was 60 hemodialysis patients; they were grouped by dietary protein intake: low protein intake group (LPI, protein intake or = 1.0 g/kg IBW, 12 men and 18 women). Blood biochemical parameters, nutrient intake, and dietary behaviors were compared between the LPI and API groups. The LPI group showed a significantly lower serum level of albumin and higher serum level of hs-CRP than the API group (p < 0.05). The LPI group showed a significantly lower intake of most nutrients than the API group (p < 0.05). Index of Nutritional Quality of most nutrients of the LPI and API groups were lower than 1.0. Dietary protein intake was positively correlated with the serum level of albumin (r = 0.306, p < 0.05) and negatively correlated with the serum level of hs-CRP (r = -0.435, p < 0.01). The serum level of hs-CRP was negatively correlated with that of albumin (r = -0.393, p < 0.01). According to these result, serum albumin and hs-CRP in HD patients were influenced by the protein intake levels. To prevent MIA syndrome, it is necessary to improve nutritional status, especially in protein and energy.
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Texto completo:
1
Índice:
WPRIM
Assunto principal:
Albumina Sérica
/
Proteínas Alimentares
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Doenças Cardiovasculares
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Estado Nutricional
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Fatores de Risco
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Mortalidade
/
Diálise Renal
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Desnutrição Proteico-Calórica
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Insuficiência Renal Crônica
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Valor Nutritivo
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
/
Male
Idioma:
Ko
Revista:
Journal of Nutrition and Health
Ano de publicação:
2013
Tipo de documento:
Article