Association of MCP-1 polymorphism with cardiovascular disease risk factors in Korean elderly / 한국영양학회지
Journal of Nutrition and Health
;
: 511-520, 2013.
Artigo
em Coreano
| WPRIM
| ID: wpr-93177
ABSTRACT
Monocyte chemoattractant protein-1 (MCP-1) plays an important role in cardiovascular disease (CVD). Genetic polymorphism in the regulatory regions of MCP-1 could affect MCP-1 expression. The purpose of the study was to explore the possible association of MCP-1 -2518 A/G genetic polymorphism and CVD risk factors in the elderly Korean population. Dietary, anthropometric, and biochemical factors were assessed in 168 subjects. The frequency of A/A, G/A, and G/G genotypes was 14.2%, 45.8%, and 40.0%, respectively. The blood level of MCP-1 was significantly higher in subjects with A/A genotype. The MCP-1 level was significantly higher in A/A genotype with hypercholesterolemia than in other genotypes. Meat intake and percent energy from lipids were significantly positively correlated with the MCP-1 level, especially, stronger in A/A genotype. In the stepwise discriminant analysis, TNF-alpha level, meat intake, HDL-C were associated with MCP-1 in all subjects (model R2 = 24%). TNF-alpha level, sugar intake, cholesterol intake, and meat intake affected MCP-1 in A/A genotype (model R2 = 82%), but not in G/A or G/G. In conclusion, subjects possessing A/A genotype exhibited higher levels of MCP-1 than other genotypes in Korean elders. Further, meat, sugar, and cholesterol intakes affected the MCP-1 level. Therefore, the decrement of meat, sugar, and cholesterol intakes helps to normalize the MCP-1 level and can decrease CVD risk in A/A genotype.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Polimorfismo Genético
/
Doenças Cardiovasculares
/
Sequências Reguladoras de Ácido Nucleico
/
Colesterol
/
Fatores de Risco
/
Fator de Necrose Tumoral alfa
/
Quimiocina CCL2
/
Genótipo
/
Hipercolesterolemia
/
Carne
Tipo de estudo:
Estudo de etiologia
/
Estudo prognóstico
/
Fatores de risco
Limite:
Idoso
/
Humanos
Idioma:
Coreano
Revista:
Journal of Nutrition and Health
Ano de publicação:
2013
Tipo de documento:
Artigo
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