Neural mechanism of abnormal mood regulation in patients with eating disorder / 中华行为医学与脑科学杂志

ABSTRACT

Eating disorder (ED) is a kind of chronic refractory mental disorder with high prevalence rate, high recurrence rate, high disability rate and heavy social burden.There is a close relationship between eating disorder and emotional regulation.More and more studies have shown that ED patients have abnormal emotional regulation.Emotional disorder is a feature of ED patients, and ED patients are easy to take abnormal eating ways to relieve their negative emotions.Studies have shown that the amygdala, ventral striatum (VS), nucleus accumbens (NAc), anterior cingulate cortex (ACC), prefrontal cortex (PFC) and subcallosal components (SCC) are crucial for emotion regulation and homeostasis.The structural and functional changes of these brain regions are closely related to emotional stimuli and impaired regulation in patients with ED.The purpose of this review is to summarize the neural mechanism of ED abnormal emotion regulation and discuss the future research direction.