Characteristics and clinical diagnostic value of multiparametric magnetic resonance imaging for prostate cancer / 中国医师杂志

ABSTRACT

Objective:To study the characteristics and clinical diagnostic value of multiparametric magnetic resonance imaging (mp-MRI) for prostate cancer (PCa).Methods:The clinical data of patients with PCa and benign prostatic hyperplasia (BPH) treated in Qinhuangdao Second Hospital from January 2019 to December 2019 were retrospectively analyzed. They were divided into PCa group and BPH group. T2-weighted imaging (T2WI), diffusion weighted imaging (DWI) and dynamic contrast enhanced (DCE)-MRI were performed respectively. The T2WI image characteristics, peripheral band and transitional band apparent diffusion coefficient (ADC) values and DCE-MRI image types were compared between the two groups. Patients in the two groups were evaluated by Prostate Imaging Reporting and Data System (PI-RADS) v2 Score. Receiver operating characteristic (ROC) curve was used to analyze the value of mp-MRI sequences in the differential diagnosis of PCA and BPH.Results:There were significant differences in image features of T2WI and DWI between PCa group and BPH group; the ADC values of both patients in peripheral zone were significantly higher than those in transition zone (all P<0.05); the ADC values of PCa patients in peripheral zone and transition zone were significantly lower than those of BPH patients (all P<0.05). There were statistically significant differences in the types of DCE-MRI images in PCa and BPH patients ( P<0.05), and the Tmax of PCa patients was significantly lower than that of BPH patients ( P<0.05), while the SImax was significantly higher than that of BPH patients ( P<0.05). PI-RADS v2 Score showed that there were statistically significant differences in the T2WI and DWI scores between PCa patients and BPH patients ( P<0.05), and the positive rates of DCE-MRI in the two groups were 94.00% and 24.00% respectively ( P<0.05). ROC curve analysis showed that the sensitivity of T2WI, DWI, DCE-MRI and combined diagnosis of PCa and BPH were 64.0%, 76.0%, 94.0% and 96.0% respectively, and the specificity were 90.0%, 92.0%, 76.0% and 84.0%. Conclusions:mp-MRI sequences have many differences in PCa and BPH. Combined with RI-RADS v2, it can effectively identify and is of great significance for improving the early diagnosis of PCa.