Research progress in role of DNA methylation regulating osteogenic differentiation of mesenchymal stem cells in regulating trauma-related skeletal disorders / 中华创伤杂志

ABSTRACT

Mesenchymal stem cells (MSCs) are a kind of stem cells with self-renewal ability and multidirectional differentiation potential. At present, as the main cell source for bone tissue engineering, MSCs can be used to treat various skeletal disorders. DNA methylation is an important epigenetic mechanism involving the occurrence and development of osteoporosis, osteonecrosis and other trauma-related skeletal disorders by regulating expression of osteogenic-specific genes in osteogenic differentiation of MSCs. The authors review the research progress in regulation of skeletal disorders by DNA methylation regulating osteogenic differentiation of MSCs by overviewing DNA methylation, mechanisms of DNA methylation regulating osteogenic differentiation of MSCs involving trauma-related bone disease and related treatment measures so as to provide references for the research and treatment of trauma-related skeletal disorders.