The Effects of Vascular Endothelial Growth Factor on Capsule Formation around Silicone Implant in Rats
Archives of Aesthetic Plastic Surgery
;
: 129-134, 2016.
Artigo
em Inglês
| WPRIM
| ID: wpr-93269
ABSTRACT
BACKGROUND:
The purpose of this study was to examine the effects of a single administration of vascular endothelial growth factor (VEGF) in promoting the angiogenesis and thereby reducing the formation of capsular contracture.METHODS:
We treated 24 female Sprague-Dawley rats with (1) 5 mM Tris Buffer and 150 mM NaCl 0.1 cc, (2) VEGF 15 µg/0.1 cc, (3) VEGF 150 µg/0.1 cc during placement of the implant, or (4) VEGF 150 µg/0.1 cc and VEGF 300 µg/0.2 cc. We histopathologically measured the thickness of the capsule and the number of blood vessels.RESULTS:
All experimental groups had a significant difference in the thickness of the capsule compared to the control group (P<0.001). There was no significant difference between experimental group 2 and experimental group 3. The number of blood vessels formed around the capsule was significantly greater in all the experimental groups compared with the control group (P<0.05). There was no significant difference between the experimental groups. There was a significant negative correlation between the thickness of the capsule and the number of blood vessels (Spearman's correlation coefficient, 0.2732; P<0.0001).CONCLUSIONS:
A single administration of VEGF reduced formation of the capsule and increased the vascularity around the implant, supporting the hypothesis that prevention of tissue ischemia can be a treatment strategy for capsular contracture.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Silício
/
Silicones
/
Trometamina
/
Vasos Sanguíneos
/
Ratos Sprague-Dawley
/
Implantes de Mama
/
Contratura
/
Fator A de Crescimento do Endotélio Vascular
/
Isquemia
Limite:
Animais
/
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Archives of Aesthetic Plastic Surgery
Ano de publicação:
2016
Tipo de documento:
Artigo
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