The role of microglia in Alzheimer′s disease / 中华神经科杂志
Chinese Journal of Neurology
;
(12): 520-524, 2022.
Artigo
em Chinês
| WPRIM
| ID: wpr-933819
ABSTRACT
At present, many drugs were developed based on the main pathological feature of Alzheimer′s disease (AD) "β-amyloid cascade hypothesis and abnormal tau protein aggregation" as targets, but the efficacy is unsatisfactory. With the progress on the study of pathological mechanism of AD, the role of microglia and their related expression genes, such as TREM2, CD 33, ABCA7 gene and their related signal transduction pathways in the pathological mechanism of AD has been paid more and more attention. The study on AD biomarkers and therapeutic targets based on microglia and their related expression genes has also increased significantly. This review will mainly focus on the pathophysiology of microglia, the mechanism of microglia in AD, the biomarkers related to microglia and the drug treatment of AD.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Neurology
Ano de publicação:
2022
Tipo de documento:
Artigo
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