Culture of pluripotent stem cell-derived hepatocytes and organoids / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 244-248, 2022.
Artigo
em Chinês
| WPRIM
| ID: wpr-935935
ABSTRACT
Liver is one of the most important organs in the human body. Liver diseases are also a major threat to human health and longevity. Hepatic decompensation treatment is quite difficult due to multiple reasons. Extracorporeal liver support devices are unable to solve this problem, and there is a severe shortage of orthotopic liver transplant donors. Study of pluripotent stem cell-derived hepatocytes and organoids can determine not only hepatocyte fate, but also liver development, regeneration mechanisms, and pathophysiology. Furthermore, it can be used for drug screening in order to provide a stable source of functional hepatocytes for future transplantation therapy. Culture of pluripotent stem cell-derived hepatocytes and organoids has a self-organizing process similar to liver development, i.e., starting with changes in several key factors, and eventually forming functionally complex cells/organs. This paper introduces the main methods and progress of pluripotent stem cell-derived hepatocytes and organoids, with hope to provide clues for future research.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Organoides
/
Diferenciação Celular
/
Hepatócitos
/
Células-Tronco Pluripotentes
/
Células-Tronco Pluripotentes Induzidas
/
Fígado
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Hepatology
Ano de publicação:
2022
Tipo de documento:
Artigo
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