Alopecia areata in a spayed pug: clinical and immunohistochemical findings / 대한수의학회지
Korean Journal of Veterinary Research
;
: 267-269, 2015.
Artigo
em Inglês
| WPRIM
| ID: wpr-93654
ABSTRACT
A two-year-old spayed female pug presented with symmetrical hyperpigmented alopecic lesions on her axillary and inguinal regions. There were no remarkable findings in dermatologic examinations and hormonal assays. Histological examination of biopsied tissues revealed prominent lymphocytic perifolliculitis along with shrunk hair follicles. Immunohistochemistry for CD3, CD79a, CD4, and CD8 showed a positive stain for CD4 antigen around hair bulbs, suggesting CD4 positive T lymphocyte infiltration. This case suggests the possibility that CD4 T lymphocyte-mediated inflammatory reaction could be a main mechanism in canine alopecia areata. Additional studies are warranted to investigate the immunological mechanism in canine species.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Doenças Autoimunes
/
Imuno-Histoquímica
/
Linfócitos
/
Antígenos CD4
/
Folículo Piloso
/
Alopecia
/
Alopecia em Áreas
/
Cabelo
Tipo de estudo:
Estudo diagnóstico
Limite:
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Korean Journal of Veterinary Research
Ano de publicação:
2015
Tipo de documento:
Artigo
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