Cancer cells corrupt normal epithelial cells through miR-let-7c-rich small extracellular vesicle-mediated downregulation of p53/PTEN / 国际口腔科学杂志·英文版
International Journal of Oral Science
;
(4): 36-36, 2022.
Artigo
em Inglês
| WPRIM
| ID: wpr-939855
ABSTRACT
Tumor volume increases continuously in the advanced stage, and aside from the self-renewal of tumor cells, whether the oncogenic transformation of surrounding normal cells is involved in this process is currently unclear. Here, we show that oral squamous cell carcinoma (OSCC)-derived small extracellular vesicles (sEVs) promote the proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) of normal epithelial cells but delay their apoptosis. In addition, nuclear-cytoplasmic invaginations and multiple nucleoli are observed in sEV-treated normal cells, both of which are typical characteristics of premalignant lesions of OSCC. Mechanistically, miR-let-7c in OSCC-derived sEVs is transferred to normal epithelial cells, leading to the transcriptional inhibition of p53 and inactivation of the p53/PTEN pathway. In summary, we demonstrate that OSCC-derived sEVs promote the precancerous transformation of normal epithelial cells, in which the miR-let-7c/p53/PTEN pathway plays an important role. Our findings reveal that cancer cells can corrupt normal epithelial cells through sEVs, which provides new insight into the progression of OSCC.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Neoplasias Bucais
/
Carcinoma de Células Escamosas
/
Regulação para Baixo
/
Movimento Celular
/
Transformação Celular Neoplásica
/
Proteína Supressora de Tumor p53
/
MicroRNAs
/
Linhagem Celular Tumoral
/
Proliferação de Células
/
Células Epiteliais
Limite:
Humanos
Idioma:
Inglês
Revista:
International Journal of Oral Science
Ano de publicação:
2022
Tipo de documento:
Artigo
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