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Clinical Effect of Mahuang Xixin Fuzitang Combined with Acupuncture and Moxibustion in Treatment of Localized Scleroderma / 中国实验方剂学杂志
Chinese Journal of Experimental Traditional Medical Formulae ; (24): 93-98, 2022.
Artigo em Chinês | WPRIM | ID: wpr-940212
ABSTRACT
ObjectiveTo observe the clinical effect of Mahuang Xixin Fuzitang combined with acupuncture and moxibustion in the treatment of localized scleroderma. MethodA total of 95 patients with localized scleroderma treated in Wuhan No. 1 Hospital from September 2019 to October 2021 were assigned into a control group (47 patients) and an observation group (48 patients) by random number table method. The control group was treated with Centella triterpenes tablets and heparin sodium cream, and the observation group was additionally treated with Mahuang Xixin Fuzitang combined with acupuncture and moxibustion. Both groups were treated for 8 weeks, and the clinical effect was compared between groups. The traditional Chinese medicine(TCM) syndrome score (local skin sclerosis, loss of skin texture, darkening of skin pigment, scaly dry skin, etc.), serum levels of soluble interleukin-2 receptor (sIL-2R) and tumor necrosis factor-alpha (TNF-α), erythrocyte sedimentation rate (ESR), and eosinophil count (EO) were compared between before and after treatment as well as between groups. Additionally, the adverse reactions were recorded. ResultThe observation group had higher total effective rate than the control group [95.83% (46/48) vs. 82.98% (39/47), χ2=4.166 4, P<0.05]. Before treatment, the TCM syndrome score, sIL-2R, TNF-α, ESR, and EO showed no significant differences between the two groups. The 8 weeks of treatment improved the TCM syndrome score, sIL-2R, TNF-α, ESR, and EO. Moreover, the observation group was superior to the control group in these indicators (P<0.05). During the treatment, the observation group showed 1 case of abnormal liver function and 1 case of nausea and vomiting, and the control group had 1 case of nausea and vomiting, 1 case of abnormal renal function, and 1 case of abnormal liver function. The total adverse reactions of the observation group (4.17%) and the control group (6.38%) had no significant difference (χ2=0.233 9, P=0.062 86). ConclusionMahuang Xixin Fuzitang combined with acupuncture and moxibustion is safe and effective in the treatment of localized scleroderma.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Journal of Experimental Traditional Medical Formulae Ano de publicação: 2022 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Journal of Experimental Traditional Medical Formulae Ano de publicação: 2022 Tipo de documento: Artigo