Isolation and Identification of Chemical Constituents in Seeds of Sophora tonkinensis / 中国实验方剂学杂志
Chinese Journal of Experimental Traditional Medical Formulae
;
(24): 165-172, 2022.
Artigo
em Chinês
| WPRIM
| ID: wpr-940301
ABSTRACT
ObjectiveTo study the chemical constituents of the seeds of Sophora tonkinensis. MethodThe chemical constituents were isolated and purified by chromatography with MCI resin, silica gel, Sephadex LH-20, and semi-preparative high performance liquid chromatography. Their structures were identified by physicochemical properties, spectral data as well as relevant references. Meanwhile, the antibacterial activities against Helicobacter pylori of these compounds were screened by agar dilution method. ResultA total of 22 compounds were isolated from the methanol extract of the seeds of S. tonkinensis, and characterized as 4′,7-dihydroxy-6-methoxy isoflavone (1), daidzein (2), wighteone (3), dalparvone (4), 5,7-dihydroxy-4′-methoxyisoflavone (5), prunetin (6), formononetin (7), genistein (8), 5-methoxydaidzein (9), ononin (10), 7,4′-dihydroxyflavone (11), liquiritigenin (12), bayin (13), 2,4-dihydroxybenzoate (14), methyparaben (15), 4-hydroxyacetophenone (16), p-anisaldehyde (17), methyl indole-3-carboxylate (18), 4-[β-D-apiofuranoyl-(1→6)-O-β-D-glucopyranosyloxy] phenylacetonitrile (19), (-)-methyl dihydrophaseate (20), methyl canavaliol ester (21), vomifoliol 3′-O-β-D-apiofuranosyl-(1→6)-β-D-glucopyranoside (22). ConclusionCompounds 1, 5, 6, 9 and 16 are isolated from S. tonkinensis for the first time, compounds 4, 14, 17-22 are isolated from the genus of Sophora for the first time. In addition, compounds 10 and 13 display moderate antibacterial activities against H. pylori.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo diagnóstico
Idioma:
Chinês
Revista:
Chinese Journal of Experimental Traditional Medical Formulae
Ano de publicação:
2022
Tipo de documento:
Artigo
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