Research advances in the mechanism of abnormal bile acid metabolism caused by gene mutation / 临床肝胆病杂志
Journal of Clinical Hepatology
; (12): 2136-2140, 2022.
Article
em Zh
| WPRIM
| ID: wpr-942675
Biblioteca responsável:
WPRO
ABSTRACT
Bile acids are synthesized and catabolized by the liver, and many factors can lead to disorders in the production, secretion, and reabsorption of bile acids, thereby causing abnormal bile acid metabolism in vivo . Common predisposing factors include hepatitis, viruses, alcohol, drugs, biliary obstruction, and inheritance. It has been reported that abnormal bile acid metabolism is associated with transporter gene mutation, and in-depth studies have been conducted in China and globally. This article reviews the mechanism of abnormal bile acid metabolism caused by gene mutations and related research advances, so as to provide a new basis and new ideas for the diagnosis and treatment of such diseases.
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Índice:
WPRIM
Idioma:
Zh
Revista:
Journal of Clinical Hepatology
Ano de publicação:
2022
Tipo de documento:
Article