Advances in basic and translational research in neuroendocrine neoplasms / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery
;
(12): 867-874, 2021.
Artigo
em Chinês
| WPRIM
| ID: wpr-942984
ABSTRACT
With the development of diagnostic techniques and the improvement of people's living standards, the detection rate of neuroendocrine tumor has been increasing and people are paying more and more attention to it. With multiple treatment modalities, the clinical research progress of neuroendocrine tumor is remarkable. However, due to the tumor heterogeneity, metastasis and recurrence of neuroendocrine tumor remains a difficult problem for clinicians. The efficacy of neuroendocrine tumor still needs to be improved. Therefore, the biological behavior of neuroendocrine tumor needs to be further studied. In recent years, with the development of molecular biology, the basic and transformation research of neuroendocrine tumor has made some progress. In this paper, we focus on the hot topics of neuroendocrine tumor, such as multiomics (copy number variation, genomics, transcriptomics), tumor microenvironment (immune microenvironment, tumor microvasculature, tumor-associated fibroblasts, etc.), preclinical research model construction (cell lines, organoids, patient derived xenograft models, genetically engineered mice), etc. Specifically, the related clinical transformation significance will be elaborated.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Tumores Neuroendócrinos
/
Variações do Número de Cópias de DNA
/
Pesquisa Translacional Biomédica
/
Microambiente Tumoral
/
Recidiva Local de Neoplasia
Tipo de estudo:
Guia de Prática Clínica
Limite:
Animais
Idioma:
Chinês
Revista:
Chinese Journal of Gastrointestinal Surgery
Ano de publicação:
2021
Tipo de documento:
Artigo
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