Research progress on laboratory examination index of clinical prognosis in individualization of cyclosporine A / 中国药房
China Pharmacy
;
(12): 2285-2289, 2022.
Artigo
em Chinês
| WPRIM
| ID: wpr-943074
ABSTRACT
Cyclosporine A is widely used in organ transplantation and autoimmune diseases . Due to the obvious differences in metabolism between individuals ,the dosage should be adjusted according to the patient ’s blood concentration during clinical use . But the blood concentration does not reflect accurately its clinical prognosis . This article focuses on the four laboratory examination indexes following aspects :the cyclosporine A concentration of peripheral blood mononuclear cells ,calcineurin activity ,T cell function and metabolite concentration of cyclosporine A . The relationship between them and the pharmacokinetics of cyclosporine and clinical prognosis were reviewed . It’s found that the above indicators have a certain predictive effect on the clinical prognosis of patients receiving cyclosporine A ,which can make up for the insufficiency of blood drug concentration monitoring ,and the clinical practicability needs to be further improved .
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo prognóstico
Idioma:
Chinês
Revista:
China Pharmacy
Ano de publicação:
2022
Tipo de documento:
Artigo
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