Change of neutrophil count after treatment of intravenous immunoglobulin in children with idiopathic thrombocytopenic purpura / 소아과
Korean Journal of Pediatrics
;
: 204-208, 2008.
Artigo
em Coreano
| WPRIM
| ID: wpr-94454
ABSTRACT
PURPOSE:
The aim of this study was to investigate the incidence and course of neutropenia following intravenous immunoglobulin (IVIG) therapy in children with idiopathic thrombocytopenic purpura (ITP).METHODS:
From January 2001 to June 2006, fifty-four patients with ITP were enrolled in this study. Forty-two of 54 patients were treated with IVIG, while the other 12 were treated with anti-D immunoglobulin (Anti-D Ig). Post-treatment absolute neutrophil counts (ANC) were compared between patients who received IVIG and those who received Anti-D Ig. Comparison of post-treatment ANC between patients who treated with two different IVIG regimens (400 mg/kg/day for 5 days and 1 g/kg/day for 2 days) was also performed.RESULTS:
Pretreatment ANC were not significantly different between the two treatment groups. After treatment with IVIG, 32 out of 42 patients (76.2%) showed more than 50% decrease of ANC from the baseline. On the other hand, only 2 out of 12 patients (16.7%) showed more than 50% decrease of ANC from the baseline after treatment Anti-D Ig. No significant difference was observed in the decline of ANC between the first IVIG treatment (42 patients) and repeated IVIG treatment groups (7 patients). There was no statistical difference in post-treatment ANC between patients who treated with two different IVIG regimens. The neutropenia induced by IVIG had resolved spontaneously in 38 out of 39 patients (97%) after several days.CONCLUSION:
Neutropenia following IVIG administration may not be an uncommon finding in children with ITP. It seems to be transient and self limited.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Imunoglobulinas
/
Incidência
/
Púrpura Trombocitopênica Idiopática
/
Imunoglobulinas Intravenosas
/
Mãos
/
Isoanticorpos
/
Neutropenia
/
Neutrófilos
Tipo de estudo:
Estudo de incidência
/
Estudo prognóstico
Limite:
Criança
/
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Pediatrics
Ano de publicação:
2008
Tipo de documento:
Artigo
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