The Prevalence and Clinical Characteristics of Hepatitis-delta Infection in Korea / 대한간학회지
The Korean Journal of Hepatology
;
: 43-50, 2005.
Artigo
em Coreano
| WPRIM
| ID: wpr-94682
ABSTRACT
BACKGROUND/AIMS:
The prevalence of hepatitis delta virus (HDV) infection has been estimated as being approximately 5% among global HBsAg carriers. The anti-delta positive rate in Koreans had been reported as being 0.85% in 1985. While the prevalence of HBV has been decreased from nearly 10% to 5% during the past twenty years, there have been no more studies on the anti-delta prevalence in Koreans. The aim of this study was to estimate the anti-delta prevalence in Koreans and to study the clinical characteristics of anti-delta positive patients in a single center.METHODS:
Serum anti-delta was measured in one hundred ninety four HBsAg-positive patients who were admitted to our hospital from February 2003 to August 2003. We checked the genotypes of the HBV in the anti-delta positive patients. The clinical features of the anti-delta positive patients were compared to those clinical features of the anti-delta negative patients from the aspect of age, gender, mode of transmission, the positivity of HBeAg and serum HBV DNA.RESULTS:
Serum anti-delta was positive in seven patients among the 194 subjects, giving a 3.6% positive rate. Among these seven patients, six had hepatocellular carcinoma (HCC) and the other one had cholangiocarcinoma. All of the anti-delta positive patients had the C genotype of HBV. The anti-delta positive patients showed significantly suppressed HBV DNA replication compared to the anti-delta negative patients.CONCLUSIONS:
In Koreans, anti-delta was positive mainly in HCC patients with an approximate prevalence of 4%, and this rate has not changed much for the past twenty years. HBV DNA replication was suppressed by HDV infection.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Hepatite D
/
Resumo em Inglês
/
Vírus Delta da Hepatite
/
Anticorpos Anti-Hepatite
/
Prevalência
/
Carcinoma Hepatocelular
/
Antígenos da Hepatite delta
/
Coreia (Geográfico)
/
Neoplasias Hepáticas
Tipo de estudo:
Estudo de prevalência
/
Fatores de risco
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
Ásia
Idioma:
Coreano
Revista:
The Korean Journal of Hepatology
Ano de publicação:
2005
Tipo de documento:
Artigo
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