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BCG-Induced Dendritic Cell Responses and Suppression of Interleukin-5 Production from T Cells in Atopic Asthmatics
Journal of Korean Medical Science ; : 628-634, 2008.
Artigo em Inglês | WPRIM | ID: wpr-9476
ABSTRACT
Bacille Calmette-Guerin (BCG) induces potent Th1 responses with the help of interleukin (IL)-10 and IL-12 released from dendritic cells (DCs), and suppresses Th2- associated allergic reactions. However, there are still some controversies on therapeutic effects of BCG in asthmatics. This study investigated whether BCG administration to DCs suppresses IL-5 production from T cells in atopic asthmatics. DCs derived from peripheral blood of subjects were cultured with or without BCG and Dermatophagoides farinae extract. Some DCs were co-cultured with T cells in the presence of BCG or the above culture supernatants. In the atopic asthmatics, BCG significantly increased IL-10 and IL-12 production from DCs. In the presence of D. farinae extract, BCG further increased IL-10 production. BCG-induced IL-10 production was significantly higher in the atopics (n=14) than in the non-atopics (n=9). Both BCG and the BCG-treated DCs culture supernatant significantly increased IFN-gamma production from T cells. Both BCG and the supernatant from DCs+BCG+D. farinae co-cultures significantly decreased IL-5 production (all p<0.05), but the supernatant from DCs+BCG co-cultures did not. In conclusion, administration of BCG together with D. farinae extract effectively decreased IL-5 production from T cells, probably through the action of IL-10 and IL-12 released from DCs in D. farinaesensitive asthmatics.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Asma / Células Dendríticas / Vacina BCG / Ativação Linfocitária / Linfócitos T / Interleucina-5 / Interferon gama / Interleucina-10 / Interleucina-12 Limite: Adulto / Feminino / Humanos / Masculino Idioma: Inglês Revista: Journal of Korean Medical Science Ano de publicação: 2008 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Asma / Células Dendríticas / Vacina BCG / Ativação Linfocitária / Linfócitos T / Interleucina-5 / Interferon gama / Interleucina-10 / Interleucina-12 Limite: Adulto / Feminino / Humanos / Masculino Idioma: Inglês Revista: Journal of Korean Medical Science Ano de publicação: 2008 Tipo de documento: Artigo