A Case of Acute Liver Failure Associated with Methimazole in Patient with Underlying Liver Disease
Soonchunhyang Medical Science
;
: 195-200, 2014.
Artigo
em Coreano
| WPRIM
| ID: wpr-95055
ABSTRACT
We report a case of methimazole-induced acute hepatic failure, which occurred 4 days after initiation of drug in a 51-year-old man with hyperthyroidism. Liver function was evaluated before taking methimazole, total bilirubin was 14.2 mg/dL. This finding suggested toxic hepatitis d/t herbal medication or unknown liver disease. He was treated with methimazole with increasing doses from 15 to 45 mg/day, he developed liver failure gradually, despite of suspending methimazole. From the time of admission, his liver function test was abnormal and liver cirrhosis was suspected by liver sonography. With aggravated liver function, he died of renal failure, sepsis of unknown origin and respiratory failure. Fulminant hepatitis rarely occurs in methimazole users, and spontaneous recovery is expected. But this case shows that methimazole-induced hepatotoxicity with possible underlying liver disease could increase the risk of poor outcomes. And in case of continued deterioration of liver function, prompt liver transplatation should be considered.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Insuficiência Respiratória
/
Bilirrubina
/
Doença de Graves
/
Transplante de Fígado
/
Falência Hepática Aguda
/
Falência Hepática
/
Sepse
/
Insuficiência Renal
/
Doença Hepática Induzida por Substâncias e Drogas
/
Hepatite
Limite:
Humanos
Idioma:
Coreano
Revista:
Soonchunhyang Medical Science
Ano de publicação:
2014
Tipo de documento:
Artigo
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